One-pot synthesis of ultra-stable polyvinylpyrrolidone-modified MnO2 nanoparticles for efficient radiation protection

Yi Zhou, Ziyu Wang, Yang Pei, Li Liu, Chang Liu, Cheng Wang*, Daoben Hua*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Radiobiological damage can be caused by radiation, and easy preparation of long-term stable radioprotectors is helpful for timely and efficient response to radiation emergencies. This study develops an ultra-stable radioprotector for rapid nuclear emergency with a simple preparing method. First of all, polyvinylpyrrolidone-modified MnO2 nanoparticles (PVP-MnO2 NPs) are obtained by one-pot synthesis with ultra-stability (remaining for at least three years) and multiple free radical scavenging activities. In the synthesis process, PVP acts as a reducing agent, a surfactant (soft template), and a steric stabilizer. PVP-MnO2 NPs can improve the survival rates of irradiated cells by effectively scavenging free radicals and protecting DNA from radiation damage. Besides, PVP-MnO2 NPs can also prevent peripheral blood cell and organ damage induced by radiation, and improve the survival rate of irradiated mice. Finally, PVP-MnO2 NPs are mainly metabolized by liver and kidney in mice, and basically excreted 72 h after administration. These results indicate that PVP-MnO2 NPs exhibit good biosafety and radioprotection activity, which is significant for the development of radioprotection agents.

Original languageEnglish
Article number113614
JournalColloids and Surfaces B: Biointerfaces
Volume232
DOIs
Publication statusPublished - Dec 2023

Keywords

  • MnO nanoparticles
  • One-pot synthesis
  • Polyvinylpyrrolidone
  • Ultra-stable radioprotectors

Fingerprint

Dive into the research topics of 'One-pot synthesis of ultra-stable polyvinylpyrrolidone-modified MnO2 nanoparticles for efficient radiation protection'. Together they form a unique fingerprint.

Cite this