One-Pot Synthesis of α-Substituted Acrylates

Magdalini Matziari*, Yixin Xie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A simple and efficient synthetic method towards α-substituted acrylic esters has been developed using the Horner-Wadsworth-Emmons (HWE) reaction with HCHO after alkylation of phosphonoacetates in a one-pot reaction. This method allows the smooth introduction of various side-chains, such as natural amino acids and other biologically relevant substituents. The use of mild conditions, inexpensive reagents, short reaction times and simple work-up and purification steps provides an effective and general alternative to cumbersome multistep and low-yielding procedures described to date.

Original languageEnglish
Article numberso-2018-d0029-op
Pages (from-to)161-167
Number of pages7
Issue number2
Publication statusPublished - 1 Apr 2018


  • Horner-Wadsworth-Emmons reaction
  • acrylates
  • amino-acid analogues
  • one-pot synthesis
  • β-amino acids

Cite this