Neurosteroid hormone vitamin D and its utility in clinical nutrition

Allan V. Kalueff*, Pentti Tuohimaa

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

227 Citations (Scopus)


PURPOSE OF REVIEW: Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. We discuss clinical and experimental evidence of the role of vitamin D in normal and pathological brain functions, and analyze the relative importance of vitamin D-modulated brain mechanisms at different stages of life. We also outline perspectives for the use of vitamin D in clinical nutrition to prevent or treat various brain disorders. RECENT FINDINGS: Numerous brain dysfunctions are linked to vitamin D deficits and/or dysfunctions of its receptors. In both animals and humans, vitamin D serves as an important endogenous and/or exogenous regulator of neuroprotection, antiepileptic and anticalcification effects, neuro-immunomodulation, interplay with neurotransmitters and hormones, modulation of behaviors, brain ageing, and some other, less-explored, brain processes. SUMMARY: Vitamin D emerges as an important neurosteroid hormone in the brain, with a strong potential for age-specific applications in clinical nutrition.

Original languageEnglish
Pages (from-to)12-19
Number of pages8
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Issue number1
Publication statusPublished - Jan 2007
Externally publishedYes


  • Neurosteroid hormone
  • Supplementation and therapy
  • Vitamin D


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