Multiple Sclerosis Recognition by Biorthogonal Wavelet Features and Fitness-Scaled Adaptive Genetic Algorithm

Aim: Multiple sclerosis (MS) is a disease, which can affect the brain and/or spinal cord, leading to a wide range of potential symptoms. This method aims to propose a novel MS recognition method. Methods: First, the bior4.4 wavelet is used to extract multiscale coefficients. Second, three types of biorthogonal wavelet features are proposed and calculated. Third, fitness-scaled adaptive genetic algorithm (FAGA)—a combination of standard genetic algorithm, adaptive mechanism, and power-rank fitness scaling—is harnessed as the optimization algorithm. Fourth, multiple-way data augmentation is utilized on the training set under the setting of 10 runs of 10-fold cross-validation. Our method is abbreviated as BWF-FAGA. Results: Our method achieves a sensitivity of 98.00 ± 0.95%, a specificity of 97.78 ± 0.95%, and an accuracy of 97.89 ± 0.94%. The area under the curve of our method is 0.9876. Conclusion: The results show that the proposed BWF-FAGA method is better than 10 state-of-the-art MS recognition methods, including eight artificial intelligence-based methods, and two deep learning-based methods.