TY - JOUR
T1 - MRI and CT compatible asymmetric bilayer hydrogel electrodes for EEG-based brain activity monitoring
AU - Ren, Guoqiang
AU - Zhang, Mingxuan
AU - Zhuang, Liping
AU - Li, Lianhui
AU - Zhao, Shunying
AU - Guo, Jinxiu
AU - Zhao, Yinchao
AU - Peng, Zhaoxiang
AU - Lian, Jiangfan
AU - Liu, Botao
AU - Ma, Jingyun
AU - Hu, Xiaodong
AU - Zhang, Zhewei
AU - Zhang, Ting
AU - Lu, Qifeng
AU - Hao, Mingming
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12
Y1 - 2024/12
N2 - The exploration of multi-dimensional brain activity with high temporal and spatial resolution is of great significance in the diagnosis of neurological disease and the study of brain science. Although the integration of electroencephalogram (EEG) with magnetic resonance imaging (MRI) and computed tomography (CT) provides a potential solution to achieve a brain-functional image with high spatiotemporal resolution, the critical issues of interface stability and magnetic compatibility remain challenging. Therefore, in this research, we proposed a conductive hydrogel EEG electrode with an asymmetrical bilayer structure, which shows the potential to overcome the challenges. Benefiting from the bilayer structure with different moduli, the hydrogel electrode exhibits high biological and mechanical compatibility with the heterogeneous brain-electrode interface. As a result, the impedance can be reduced compared with conventional metal electrodes. In addition, the hydrogel-based ionic conductive electrodes, which are free from metal conductors, are compatible with MRI and CT. Therefore, they can obtain high spatiotemporal resolution multi-dimensional brain information in clinical settings. The research outcome provides a new approach for establishing a platform for early diagnosis of brain diseases and the study of brain science. (Figure presented.)
AB - The exploration of multi-dimensional brain activity with high temporal and spatial resolution is of great significance in the diagnosis of neurological disease and the study of brain science. Although the integration of electroencephalogram (EEG) with magnetic resonance imaging (MRI) and computed tomography (CT) provides a potential solution to achieve a brain-functional image with high spatiotemporal resolution, the critical issues of interface stability and magnetic compatibility remain challenging. Therefore, in this research, we proposed a conductive hydrogel EEG electrode with an asymmetrical bilayer structure, which shows the potential to overcome the challenges. Benefiting from the bilayer structure with different moduli, the hydrogel electrode exhibits high biological and mechanical compatibility with the heterogeneous brain-electrode interface. As a result, the impedance can be reduced compared with conventional metal electrodes. In addition, the hydrogel-based ionic conductive electrodes, which are free from metal conductors, are compatible with MRI and CT. Therefore, they can obtain high spatiotemporal resolution multi-dimensional brain information in clinical settings. The research outcome provides a new approach for establishing a platform for early diagnosis of brain diseases and the study of brain science. (Figure presented.)
UR - http://www.scopus.com/inward/record.url?scp=85207695057&partnerID=8YFLogxK
U2 - 10.1038/s41378-024-00805-2
DO - 10.1038/s41378-024-00805-2
M3 - Article
AN - SCOPUS:85207695057
SN - 2055-7434
VL - 10
JO - Microsystems and Nanoengineering
JF - Microsystems and Nanoengineering
IS - 1
M1 - 156
ER -