Mouse models for studying depression-like states and antidepressant drugs

Carisa L. Bergner*, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. Laporte, Allan V. Kalueff

*Corresponding author for this work

Research output: Chapter in Book or Report/Conference proceedingChapterpeer-review

18 Citations (Scopus)

Abstract

Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity with other brain dysfunctions. Due to this complexity, little is known about the neural and genetic mechanisms involved in depression pathogenesis. In a large proportion of patients, current antidepressant treatments are often ineffective and/or have undesirable side effects, fueling the search for more effective drugs. Animal models mimicking various symptoms of depression are indispensable in studying the biological mechanisms of this disease. Here, we summarize several popular methods for assessing depression-like symptoms in mice and their utility in screening antidepressant drugs.

Original languageEnglish
Title of host publicationMouse Models for Drug Discovery
Subtitle of host publicationMethods and Protocols
EditorsGabriele Proetzel, Michael Wiles
Pages267-282
Number of pages16
DOIs
Publication statusPublished - 2010
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume602
ISSN (Print)1064-3745

Keywords

  • anhedonia
  • animal models
  • antidepressant drug screening
  • chronic stress
  • Depression
  • despair

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