Molecular psychiatry of zebrafish

A. M. Stewart; J. F.P. Ullmann; W. H.J. Norton; M. O. Parker; C. H. Brennan; R. Gerlai; A. V. Kalueff

doi:10.1038/mp.2014.128

Molecular psychiatry of zebrafish

A. M. Stewart^*, J. F.P. Ullmann, W. H.J. Norton, M. O. Parker, C. H. Brennan, R. Gerlai, A. V. Kalueff

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

163 Citations (Scopus)

Abstract

Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.

Original language	English
Pages (from-to)	2-17
Number of pages	16
Journal	Molecular Psychiatry
Volume	20
Issue number	1
DOIs	https://doi.org/10.1038/mp.2014.128
Publication status	Published - 5 Feb 2015
Externally published	Yes

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10.1038/mp.2014.128

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AU - Ullmann, J. F.P.

AU - Norton, W. H.J.

AU - Parker, M. O.

AU - Brennan, C. H.

AU - Gerlai, R.

AU - Kalueff, A. V.

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AB - Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.

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Molecular psychiatry of zebrafish

Abstract

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