Modeling withdrawal syndrome in zebrafish

Jonathan Cachat; Peter Canavello; Marco Elegante; Brett Bartels; Peter Hart; Carisa Bergner; Rupert Egan; Ashley Duncan; David Tien; Amanda Chung; Keith Wong; Jason Goodspeed; Julia Tan; Chelsea Grimes; Salem Elkhayat; Christopher Suciu; Michael Rosenberg; Kyung Min Chung; Ferdous Kadri; Sudipta Roy; Siddharth Gaikwad; Adam Stewart; Ivan Zapolsky; Thomas Gilder; Sopan Mohnot; Esther Beeson; Hakima Amri; Zofia Zukowska; R. Denis Soignier; Allan V. Kalueff

doi:10.1016/j.bbr.2009.12.004

Modeling withdrawal syndrome in zebrafish

Jonathan Cachat, Peter Canavello, Marco Elegante, Brett Bartels, Peter Hart, Carisa Bergner, Rupert Egan, Ashley Duncan, David Tien, Amanda Chung, Keith Wong, Jason Goodspeed, Julia Tan, Chelsea Grimes, Salem Elkhayat, Christopher Suciu, Michael Rosenberg, Kyung Min Chung, Ferdous Kadri, Sudipta RoySiddharth Gaikwad, Adam Stewart, Ivan Zapolsky, Thomas Gilder, Sopan Mohnot, Esther Beeson, Hakima Amri, Zofia Zukowska, R. Denis Soignier, Allan V. Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

158 Citations (Scopus)

Abstract

The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral neuroscience research. Zebrafish behavior is robustly affected by environmental and pharmacological manipulations, and can be examined using exploration-based paradigms, paralleled by analysis of endocrine (cortisol) stress responses. Discontinuation of various psychotropic drugs evokes withdrawal in both humans and rodents, characterized by increased anxiety. Sensitivity of zebrafish to drugs of abuse has been recently reported in the literature. Here we examine the effects of ethanol, diazepam, morphine and caffeine withdrawal on zebrafish behavior. Overall, discontinuation of ethanol, diazepam and morphine produced anxiogenic-like behavioral or endocrine responses, demonstrating the utility of zebrafish in translational research of withdrawal syndrome.

Original language	English
Pages (from-to)	371-376
Number of pages	6
Journal	Behavioural Brain Research
Volume	208
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2009.12.004
Publication status	Published - 2 Apr 2010
Externally published	Yes

Keywords

Anxiety
Cortisol
Novel tank test
Stress
Withdrawal
Zebrafish

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10.1016/j.bbr.2009.12.004

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Cachat, J., Canavello, P., Elegante, M., Bartels, B., Hart, P., Bergner, C., Egan, R., Duncan, A., Tien, D., Chung, A., Wong, K., Goodspeed, J., Tan, J., Grimes, C., Elkhayat, S., Suciu, C., Rosenberg, M., Chung, K. M., Kadri, F., ... Kalueff, A. V. (2010). Modeling withdrawal syndrome in zebrafish. Behavioural Brain Research, 208(2), 371-376. https://doi.org/10.1016/j.bbr.2009.12.004

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abstract = "The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral neuroscience research. Zebrafish behavior is robustly affected by environmental and pharmacological manipulations, and can be examined using exploration-based paradigms, paralleled by analysis of endocrine (cortisol) stress responses. Discontinuation of various psychotropic drugs evokes withdrawal in both humans and rodents, characterized by increased anxiety. Sensitivity of zebrafish to drugs of abuse has been recently reported in the literature. Here we examine the effects of ethanol, diazepam, morphine and caffeine withdrawal on zebrafish behavior. Overall, discontinuation of ethanol, diazepam and morphine produced anxiogenic-like behavioral or endocrine responses, demonstrating the utility of zebrafish in translational research of withdrawal syndrome.",

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Cachat, J, Canavello, P, Elegante, M, Bartels, B, Hart, P, Bergner, C, Egan, R, Duncan, A, Tien, D, Chung, A, Wong, K, Goodspeed, J, Tan, J, Grimes, C, Elkhayat, S, Suciu, C, Rosenberg, M, Chung, KM, Kadri, F, Roy, S, Gaikwad, S, Stewart, A, Zapolsky, I, Gilder, T, Mohnot, S, Beeson, E, Amri, H, Zukowska, Z, Soignier, RD & Kalueff, AV 2010, 'Modeling withdrawal syndrome in zebrafish', Behavioural Brain Research, vol. 208, no. 2, pp. 371-376. https://doi.org/10.1016/j.bbr.2009.12.004

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AU - Cachat, Jonathan

AU - Canavello, Peter

AU - Elegante, Marco

AU - Bartels, Brett

AU - Hart, Peter

AU - Bergner, Carisa

AU - Egan, Rupert

AU - Duncan, Ashley

AU - Tien, David

AU - Chung, Amanda

AU - Wong, Keith

AU - Goodspeed, Jason

AU - Tan, Julia

AU - Grimes, Chelsea

AU - Elkhayat, Salem

AU - Suciu, Christopher

AU - Rosenberg, Michael

AU - Chung, Kyung Min

AU - Kadri, Ferdous

AU - Roy, Sudipta

AU - Gaikwad, Siddharth

AU - Stewart, Adam

AU - Zapolsky, Ivan

AU - Gilder, Thomas

AU - Mohnot, Sopan

AU - Beeson, Esther

AU - Amri, Hakima

AU - Zukowska, Zofia

AU - Soignier, R. Denis

AU - Kalueff, Allan V.

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KW - Cortisol

KW - Novel tank test

KW - Stress

KW - Withdrawal

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VL - 208

SP - 371

EP - 376

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

ER -

Modeling withdrawal syndrome in zebrafish

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Keywords

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