Modeling the drug withdrawal syndrome in zebrafish (Danio rerio)

Konstantin N. Zabegalov, David S. Galstyan, Tatyana O. Kolesnikova, Yurii M. Kositsyn, Mariya A. Gubaidullina, Gleb O. Maslov, Konstantin A. Demin, Sergey L. Khatsko, Allan V. Kalueff*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The central pathological link in addictive states is the drug withdrawal syndrome. Usually, severe manifestations of the withdrawal syndrome are associated with reduced sensitivity of postsynaptic receptors (desensitization), lower den-sity of receptors and impaired transport of neurotransmitters, and the rebound effect. Zebrafish is an effective tool in the study of classic withdrawal symptoms and special cases of withdrawal of other selected psychoactive drugs.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalReviews on Clinical Pharmacology and Drug Therapy
Volume20
Issue number2
DOIs
Publication statusPublished - 2022
Externally publishedYes

Keywords

  • addiction
  • ethanol
  • morphine
  • withdrawal syndrome
  • zebrafish

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