Abstract
The central pathological link in addictive states is the drug withdrawal syndrome. Usually, severe manifestations of the withdrawal syndrome are associated with reduced sensitivity of postsynaptic receptors (desensitization), lower den-sity of receptors and impaired transport of neurotransmitters, and the rebound effect. Zebrafish is an effective tool in the study of classic withdrawal symptoms and special cases of withdrawal of other selected psychoactive drugs.
Original language | English |
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Pages (from-to) | 185-191 |
Number of pages | 7 |
Journal | Reviews on Clinical Pharmacology and Drug Therapy |
Volume | 20 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2022 |
Externally published | Yes |
Keywords
- addiction
- ethanol
- morphine
- withdrawal syndrome
- zebrafish