Modeling depression in zebrafish

David S. Galstyan, Tatyana O. Kolesnikova, Yurii M. Kositsyn, Konstantin N. Zabegalov, Mariya A. Gubaidullina, Gleb O. Maslov, Konstantin A. Demin, Sergey L. Khatsko, Allan V. Kalueff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Depression is a widespread, severely debilitating mental disorder characterized by low mood, anhedonia, fatigue, decreased attention, suicidality and psychomotor retardation, accompanied by neuroendocrine and molecular disorders. Zebrafish have neuroendocrine and neurotransmitter systems similar to humans, as well as high genetic homology, and are rapidly becoming popular model organisms for modeling depressive-like conditions. Here, we discuss modern behavioral, pharmacological and genetic models of depression in zebrafish, their methodological applications and translational implications.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalReviews on Clinical Pharmacology and Drug Therapy
Issue number2
Publication statusPublished - 2022
Externally publishedYes


  • chronic stress
  • depression
  • despair
  • reserpine
  • zebrafish


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