Mitochondrial Medicine: A Promising Therapeutic Option Against Various Neurodegenerative Disorders

Mohannad A. Almikhlafi, Mohammed M. Karami, Ankit Jana, Thamer M. Alqurashi, Mohammed Majrashi, Badrah S. Alghamdi*, Ghulam Md Ashraf*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Abnormal mitochondrial morphology and metabolic dysfunction have been observed in many neurodegenerative disorders (NDDs). Mitochondrial dysfunction can be caused by aberrant mi-tochondrial DNA, mutant nuclear proteins that interact with mitochondria directly or indirectly, or for unknown reasons. Since mitochondria play a significant role in neurodegeneration, mitochondria-targeted therapies represent a prosperous direction for the development of novel drug compounds that can be used to treat NDDs. This review gives a brief description of how mitochondrial abnormalities lead to various NDDs such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We further explore the promising therapeutic effectiveness of mitochon-dria-directed antioxidants, MitoQ, MitoVitE, MitoPBN, and dimebon. We have also discussed the possibility of mitochondrial gene therapy as a therapeutic option for these NDDs.

Original languageEnglish
Pages (from-to)1165-1183
Number of pages19
JournalCurrent Neuropharmacology
Volume21
Issue number5
DOIs
Publication statusPublished - 2023
Externally publishedYes

Keywords

  • Alzheimer’s disease
  • amyotrophic lateral sclerosis
  • gene therapy
  • Huntington’s disease
  • mitochondrial dysfunction
  • Parkinson’s disease

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