Metal oxide based non-enzymatic electrochemical sensors for glucose detection

Qiuchen Dong, Heejeong Ryu, Yu Lei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

198 Citations (Scopus)


Glucose sensors play an important role in managing blood glucose level of diabetic patients. Although enzyme-based glucose test strips dominate glucose detection market, the intrinsic chemical and thermal sensitivity of enzymes stimulates researchers to explore chemically and thermally stable metal oxides as alternative sensing materials for non-enzymatic glucose detection. This review begins with sensing mechanisms and working principles of metal oxides based glucose sensors, followed by the discussion and summarization of recent progress of metal oxide based non-enzymatic glucose detection with a focus on electrochemical techniques. Finally, this review concludes with a discussion of future trends in developing advanced non-enzymatic glucose sensors.

Original languageEnglish
Article number137744
JournalElectrochimica Acta
Publication statusPublished - 20 Feb 2021
Externally publishedYes


  • Electrochemical
  • Glucose sensors
  • Metal oxides
  • Non-enzymatic
  • Review

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