Mechanisms of neuroprotective action of vitamin D3

A. V. Kalueff; K. O. Eremin; P. Tuohimaa

doi:10.1023/B:BIRY.0000040196.65686.2f

Mechanisms of neuroprotective action of vitamin D₃

A. V. Kalueff^*, K. O. Eremin, P. Tuohimaa

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

106 Citations (Scopus)

Abstract

This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D₃ and its receptors in the nervous system. Special attention is paid to Ca²⁺ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D₃, in the nervous system.

Original language	English
Pages (from-to)	738-741
Number of pages	4
Journal	Biochemistry (Moscow)
Volume	69
Issue number	7
DOIs	https://doi.org/10.1023/B:BIRY.0000040196.65686.2f
Publication status	Published - Jul 2004
Externally published	Yes

Keywords

Calcitriol
Nervous system
Neuroprotection
Vitamin D

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10.1023/B:BIRY.0000040196.65686.2f

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title = "Mechanisms of neuroprotective action of vitamin D3",

abstract = "This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D3 and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D3, in the nervous system.",

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AU - Eremin, K. O.

AU - Tuohimaa, P.

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N2 - This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D3 and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D3, in the nervous system.

AB - This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D3 and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D3, in the nervous system.

KW - Calcitriol

KW - Nervous system

KW - Neuroprotection

KW - Vitamin D

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U2 - 10.1023/B:BIRY.0000040196.65686.2f

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M3 - Review article

C2 - 15310271

AN - SCOPUS:4444307880

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JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

IS - 7

ER -

Mechanisms of neuroprotective action of vitamin D₃

Abstract

Keywords

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