Mechanism of DNA Methylation in Stem Cells

Yanning Cai*, Qian Dong, Anlan Li

*Corresponding author for this work

Research output: Chapter in Book or Report/Conference proceedingChapterpeer-review


DNA methylation is an important regulation mode in epigenetic mechanism. It affects a series of biological processes by regulating gene expression. As a cell population with self-renewal, high proliferation and multidirectional differentiation potential, the differentiation and regeneration process of stem cells must be accurately regulated. DNA methylation plays an important role in the maintenance, differentiation and regulation of stem cells. This paper reviews the latest research progress of DNA methylation in embryonic stem cells, pluripotent stem cells and adult stem cells, reviews and prospects the potential biological functions and regulatory mechanisms of DNA methylation in stem cells, and provides some references for clinical diagnosis, treatment and drug development in the future.

Original languageEnglish
Title of host publicationLecture Notes on Data Engineering and Communications Technologies
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages13
Publication statusPublished - 2022
Externally publishedYes

Publication series

NameLecture Notes on Data Engineering and Communications Technologies
ISSN (Print)2367-4512
ISSN (Electronic)2367-4520


  • Demethylation
  • Methylation
  • Stem cells
  • TET


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