Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats

Allan V. Kalueff; Kai A. Lehtimaki; Aarne Ylinen; Jari Honkaniemi; Jukka Peltola

doi:10.1016/j.neulet.2004.04.061

Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats

Allan V. Kalueff^*, Kai A. Lehtimaki, Aarne Ylinen, Jari Honkaniemi, Jukka Peltola

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 μl) to rats 1 h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg). Overall, compared to the saline-treated control animals (n=11 in each group), IL-6-treated rats demonstrated elevated levels of IL-6 in the frontal lobe (measured by ELISA) and increased severity of PTZ-induced seizures (shorter latency, longer duration and higher mortality). Our findings show that IL-6 plays a pro-convulsant role in the brain and suggest that the IL-6 system may be a novel target for the development of anticonvulsant drugs.

Original language	English
Pages (from-to)	106-110
Number of pages	5
Journal	Neuroscience Letters
Volume	365
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2004.04.061
Publication status	Published - 22 Jul 2004
Externally published	Yes

Keywords

Chemically induced seizures
Epilepsy
IL-6
Intranasal administration
Rat

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10.1016/j.neulet.2004.04.061

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title = "Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats",

abstract = "Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 μl) to rats 1 h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg). Overall, compared to the saline-treated control animals (n=11 in each group), IL-6-treated rats demonstrated elevated levels of IL-6 in the frontal lobe (measured by ELISA) and increased severity of PTZ-induced seizures (shorter latency, longer duration and higher mortality). Our findings show that IL-6 plays a pro-convulsant role in the brain and suggest that the IL-6 system may be a novel target for the development of anticonvulsant drugs.",

keywords = "Chemically induced seizures, Epilepsy, IL-6, Intranasal administration, Rat",

author = "Kalueff, {Allan V.} and Lehtimaki, {Kai A.} and Aarne Ylinen and Jari Honkaniemi and Jukka Peltola",

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T1 - Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats

AU - Kalueff, Allan V.

AU - Lehtimaki, Kai A.

AU - Ylinen, Aarne

AU - Honkaniemi, Jari

AU - Peltola, Jukka

PY - 2004/7/22

Y1 - 2004/7/22

N2 - Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 μl) to rats 1 h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg). Overall, compared to the saline-treated control animals (n=11 in each group), IL-6-treated rats demonstrated elevated levels of IL-6 in the frontal lobe (measured by ELISA) and increased severity of PTZ-induced seizures (shorter latency, longer duration and higher mortality). Our findings show that IL-6 plays a pro-convulsant role in the brain and suggest that the IL-6 system may be a novel target for the development of anticonvulsant drugs.

AB - Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 μl) to rats 1 h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg). Overall, compared to the saline-treated control animals (n=11 in each group), IL-6-treated rats demonstrated elevated levels of IL-6 in the frontal lobe (measured by ELISA) and increased severity of PTZ-induced seizures (shorter latency, longer duration and higher mortality). Our findings show that IL-6 plays a pro-convulsant role in the brain and suggest that the IL-6 system may be a novel target for the development of anticonvulsant drugs.

KW - Chemically induced seizures

KW - Epilepsy

KW - IL-6

KW - Intranasal administration

KW - Rat

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Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats

Abstract

Keywords

UN SDGs

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