TY - JOUR
T1 - Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats
AU - Kalueff, Allan V.
AU - Lehtimaki, Kai A.
AU - Ylinen, Aarne
AU - Honkaniemi, Jari
AU - Peltola, Jukka
PY - 2004/7/22
Y1 - 2004/7/22
N2 - Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 μl) to rats 1 h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg). Overall, compared to the saline-treated control animals (n=11 in each group), IL-6-treated rats demonstrated elevated levels of IL-6 in the frontal lobe (measured by ELISA) and increased severity of PTZ-induced seizures (shorter latency, longer duration and higher mortality). Our findings show that IL-6 plays a pro-convulsant role in the brain and suggest that the IL-6 system may be a novel target for the development of anticonvulsant drugs.
AB - Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally (400 ng/40 μl) to rats 1 h before seizures induced by systemic injection of pentylenenetrazole (PTZ, 75 mg/kg). Overall, compared to the saline-treated control animals (n=11 in each group), IL-6-treated rats demonstrated elevated levels of IL-6 in the frontal lobe (measured by ELISA) and increased severity of PTZ-induced seizures (shorter latency, longer duration and higher mortality). Our findings show that IL-6 plays a pro-convulsant role in the brain and suggest that the IL-6 system may be a novel target for the development of anticonvulsant drugs.
KW - Chemically induced seizures
KW - Epilepsy
KW - IL-6
KW - Intranasal administration
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=3042853067&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2004.04.061
DO - 10.1016/j.neulet.2004.04.061
M3 - Article
C2 - 15245788
AN - SCOPUS:3042853067
SN - 0304-3940
VL - 365
SP - 106
EP - 110
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -