@inproceedings{0774651d62c24491a09b1d517b27006d,
title = "Integrated analysis of hela cell microRNAs' microarray data and anti-cancer pathway prediction of beta-sitosterol",
abstract = "It has remarkable efficacy to treat cervical cancer cell using beta-sitosterol. At present, beta-sitosterol has been used in the clinical treatment of cancer and its side effects are remotely lower than the traditional drug such as cisplatin. However, the anticancer mechanism of beta-sitosterol is unknown in cervical cancer. In this study, we mainly use TaqMan MicroRNA Assay to detect the consequence of Hela cell treatment by beta-sitosterol and cisplatin and analyze it from molecular level. We find out the differentially expressed microRNAs and forecast their targets by Targetscan. We also provide direct evidence that STK4/MST1 is a functional target. From the viewpoint of bioinformatics, we speculate the possible pathway of beta-sitosterol to inhibit tumor.",
keywords = "STK4/MST1, beta-sitosterol, hela, microarray",
author = "Xijia Fei and Dachuang Liu and Cuihong Dai and Aiju Hou and Jianzhong Li and Dechang Xu",
year = "2012",
doi = "10.1109/BIBMW.2012.6470247",
language = "English",
isbn = "9781467327466",
series = "Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012",
pages = "824--830",
booktitle = "Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012",
note = "2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012 ; Conference date: 04-10-2012 Through 07-10-2012",
}