Inhibitory effect and molecular mechanism of the new phorphyrin-based HCE6 photosensitizer on the activity of MKN45 human gastric cancer cells

Ye Kai Tan; Kui Jie Liu; Heng Zou; Hong Liang Yao; Jie Yuan Jin; Chao Yue Zhang; Qi Zheng Li; Li Xiong; San Lin Lei; Wei Chen

doi:10.1166/jbn.2019.2774

Inhibitory effect and molecular mechanism of the new phorphyrin-based HCE6 photosensitizer on the activity of MKN45 human gastric cancer cells

Ye Kai Tan, Kui Jie Liu, Heng Zou, Hong Liang Yao, Jie Yuan Jin, Chao Yue Zhang, Qi Zheng Li, Li Xiong^*, San Lin Lei, Wei Chen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Gastric cancer is the fourth most common cancer worldwide and the third most common in Asia, with a high mortality. Photodynamic therapy (PDT) is a new treatment for cancer. With advantages of minimum invasiveness, small adverse side effects and high selectivity, PDT can be used as palliative treatment for patients with advanced gastric cancer. YLG I, also known as 2-(1 hexyloxyethyl)-2-devinyl porphin e6 trisodium salt (HCE6), is a recently developed photosensitizer. A previous study showed that HCE6 significantly inhibited the growth of QBC939 human cholangiocarcinoma cells.

Original language	English
Pages (from-to)	1345-1353
Number of pages	9
Journal	Journal of Biomedical Nanotechnology
Volume	16
Issue number	6
DOIs	https://doi.org/10.1166/jbn.2019.2774
Publication status	Published - 2019
Externally published	Yes

Keywords

Apoptosis
Gastric Cancer Cells
HCE6
Photodynamic Therapy
RNAseq

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1166/jbn.2019.2774

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title = "Inhibitory effect and molecular mechanism of the new phorphyrin-based HCE6 photosensitizer on the activity of MKN45 human gastric cancer cells",

abstract = "Gastric cancer is the fourth most common cancer worldwide and the third most common in Asia, with a high mortality. Photodynamic therapy (PDT) is a new treatment for cancer. With advantages of minimum invasiveness, small adverse side effects and high selectivity, PDT can be used as palliative treatment for patients with advanced gastric cancer. YLG I, also known as 2-(1 hexyloxyethyl)-2-devinyl porphin e6 trisodium salt (HCE6), is a recently developed photosensitizer. A previous study showed that HCE6 significantly inhibited the growth of QBC939 human cholangiocarcinoma cells.",

keywords = "Apoptosis, Gastric Cancer Cells, HCE6, Photodynamic Therapy, RNAseq",

author = "Tan, {Ye Kai} and Liu, {Kui Jie} and Heng Zou and Yao, {Hong Liang} and Jin, {Jie Yuan} and Zhang, {Chao Yue} and Li, {Qi Zheng} and Li Xiong and Lei, {San Lin} and Wei Chen",

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doi = "10.1166/jbn.2019.2774",

language = "English",

volume = "16",

pages = "1345--1353",

journal = "Journal of Biomedical Nanotechnology",

issn = "1550-7033",

number = "6",

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TY - JOUR

T1 - Inhibitory effect and molecular mechanism of the new phorphyrin-based HCE6 photosensitizer on the activity of MKN45 human gastric cancer cells

AU - Tan, Ye Kai

AU - Liu, Kui Jie

AU - Zou, Heng

AU - Yao, Hong Liang

AU - Jin, Jie Yuan

AU - Zhang, Chao Yue

AU - Li, Qi Zheng

AU - Xiong, Li

AU - Lei, San Lin

AU - Chen, Wei

PY - 2019

Y1 - 2019

N2 - Gastric cancer is the fourth most common cancer worldwide and the third most common in Asia, with a high mortality. Photodynamic therapy (PDT) is a new treatment for cancer. With advantages of minimum invasiveness, small adverse side effects and high selectivity, PDT can be used as palliative treatment for patients with advanced gastric cancer. YLG I, also known as 2-(1 hexyloxyethyl)-2-devinyl porphin e6 trisodium salt (HCE6), is a recently developed photosensitizer. A previous study showed that HCE6 significantly inhibited the growth of QBC939 human cholangiocarcinoma cells.

AB - Gastric cancer is the fourth most common cancer worldwide and the third most common in Asia, with a high mortality. Photodynamic therapy (PDT) is a new treatment for cancer. With advantages of minimum invasiveness, small adverse side effects and high selectivity, PDT can be used as palliative treatment for patients with advanced gastric cancer. YLG I, also known as 2-(1 hexyloxyethyl)-2-devinyl porphin e6 trisodium salt (HCE6), is a recently developed photosensitizer. A previous study showed that HCE6 significantly inhibited the growth of QBC939 human cholangiocarcinoma cells.

KW - Apoptosis

KW - Gastric Cancer Cells

KW - HCE6

KW - Photodynamic Therapy

KW - RNAseq

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U2 - 10.1166/jbn.2019.2774

DO - 10.1166/jbn.2019.2774

M3 - Article

C2 - 31072441

AN - SCOPUS:85065872819

SN - 1550-7033

VL - 16

SP - 1345

EP - 1353

JO - Journal of Biomedical Nanotechnology

JF - Journal of Biomedical Nanotechnology

IS - 6

ER -

Inhibitory effect and molecular mechanism of the new phorphyrin-based HCE6 photosensitizer on the activity of MKN45 human gastric cancer cells

Abstract

Keywords

UN SDGs

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