Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis

Yixue Qiao, Kaushik Maiti, Zakia Sultana, Lei Fu*, Roger Smith

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance in the development of novel drugs and therapeutic strategies. This review provides an overview of the evolution and the action mechanism of AOX and the role of each domain. The review provides an update of the polymorphisms in the human AOX. This review also summarises the physiology of AOX in different organs and its role in drug metabolism. The inhibition of AOX is a promising therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis.

Original languageEnglish
Article number111948
JournalEuropean Journal of Medicinal Chemistry
Volume187
DOIs
Publication statusPublished - 1 Feb 2020
Externally publishedYes

Keywords

  • AOX inhibition
  • Aldehyde oxidase
  • Drug metabolism
  • Evolution
  • Physiology
  • Polymorphism

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