Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases

Jalaluddin M. Ashraf*, Mohammad Azam Ansari, Sana Fatma, Saleh M.S. Abdullah, Johar Iqbal, Aymen Madkhali, Al Hassan Hamali, Saheem Ahmad, Ahmed Jerah, Valentina Echeverria, George E. Barreto, Ghulam Md Ashraf

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Advanced glycation end products (AGEs) are implicated in several central nervous system (CNS) pathologies including Alzheimer and Parkinson’s diseases. In the face-off of AGE menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were determined by biophysical immunological and biochemical techniques. The results showed that ZnONP is a potential anti-glycating agent inhibiting AGE formation as well as protecting the protein structure from change. Therefore, our findings suggest ZnONPs may be used as a therapeutic in resolving the AGE role in CNS-related complications.

Original languageEnglish
Pages (from-to)7438-7452
Number of pages15
JournalMolecular Neurobiology
Volume55
Issue number9
DOIs
Publication statusPublished - 1 Sept 2018
Externally publishedYes

Keywords

  • Advanced glycation end products
  • Anti-glycating agent
  • Nanoparticles
  • Neurodegenerative diseases

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