Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats

Ahmet H. Kaya; Rinske Vlamings; Sonny Tan; Lee Wei Lim; Peter J. Magill; Harry W.M. Steinbusch; Veerle Visser-Vandewalle; Trevor Sharp; Yasin Temel

doi:10.1016/j.brainres.2008.05.019

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats

Ahmet H. Kaya, Rinske Vlamings, Sonny Tan, Lee Wei Lim, Peter J. Magill, Harry W.M. Steinbusch, Veerle Visser-Vandewalle, Trevor Sharp, Yasin Temel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

Original language	English
Pages (from-to)	93-97
Number of pages	5
Journal	Brain Research
Volume	1221
DOIs	https://doi.org/10.1016/j.brainres.2008.05.019
Publication status	Published - 24 Jul 2008
Externally published	Yes

Keywords

Dorsal raphe nucleus
Parkinson's disease
Serotonin
Subthalamic nucleus

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10.1016/j.brainres.2008.05.019

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title = "Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats",

abstract = "Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.",

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AU - Kaya, Ahmet H.

AU - Vlamings, Rinske

AU - Tan, Sonny

AU - Lim, Lee Wei

AU - Magill, Peter J.

AU - Steinbusch, Harry W.M.

AU - Visser-Vandewalle, Veerle

AU - Sharp, Trevor

AU - Temel, Yasin

PY - 2008/7/24

Y1 - 2008/7/24

N2 - Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

AB - Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

KW - Dorsal raphe nucleus

KW - Parkinson's disease

KW - Serotonin

KW - Subthalamic nucleus

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SN - 0006-8993

VL - 1221

SP - 93

EP - 97

JO - Brain Research

JF - Brain Research

ER -

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats

Abstract

Keywords

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