Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats

Ahmet H. Kaya, Rinske Vlamings, Sonny Tan, Lee Wei Lim, Peter J. Magill, Harry W.M. Steinbusch, Veerle Visser-Vandewalle, Trevor Sharp, Yasin Temel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

Original languageEnglish
Pages (from-to)93-97
Number of pages5
JournalBrain Research
Volume1221
DOIs
Publication statusPublished - 24 Jul 2008
Externally publishedYes

Keywords

  • Dorsal raphe nucleus
  • Parkinson's disease
  • Serotonin
  • Subthalamic nucleus

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