TY - JOUR
T1 - Impact of comorbidity on lung cancer mortality - A report from the liverpool lung project
AU - Marcus, Michael W.
AU - Chen, Ying
AU - Duffy, Stephen W.
AU - Field, John K.
N1 - Publisher Copyright:
© 2015, Spandidos Publications. All Rights Reserved.
PY - 2015
Y1 - 2015
N2 - The aim of the present study was to apply the Charlson comorbidity index (CCI) to evaluate the impact of comorbidity on lung cancer mortality in individuals not exhibiting lung cancer at the commencement of follow-up. Data from 9,579 participants without lung cancer were extracted from the Liverpool Lung Project between 1999 and 2010 and linked to the Hospital Episode Statistics database. The occurrence of comorbidities was assessed one year prior to the individual inclusion date. CCI scores were computed and Cox regression analysis was used to evaluate the association between comorbidity and lung cancer mortality using a competitive risk approach. During a median follow-up of 11 years, 1,320/9,579 (13.7%) individuals developed lung cancer, of which 886 (67.1%) succumbed to lung cancer and 875 of the 9,579 individuals (9.1%) succumbed due to other causes. The severity of comorbidity was associated with higher lung cancer-specific mortality; low to moderate comorbidity exhibited a hazard ratio (HR) of 2.86 [95% confidence interval (CI), 1.17-7.02] and severe comorbidity exhibited an HR of 5.16 (95% CI, 2.07-12.89). Furthermore, the CCI score determined that the severity of comorbidity increased the risk of lung cancer-specific mortality. Thus, CCI score is a good predictor of lung cancer-specific mortality and the use of comorbidity burdens in the clinical management of lung cancer is recommended.
AB - The aim of the present study was to apply the Charlson comorbidity index (CCI) to evaluate the impact of comorbidity on lung cancer mortality in individuals not exhibiting lung cancer at the commencement of follow-up. Data from 9,579 participants without lung cancer were extracted from the Liverpool Lung Project between 1999 and 2010 and linked to the Hospital Episode Statistics database. The occurrence of comorbidities was assessed one year prior to the individual inclusion date. CCI scores were computed and Cox regression analysis was used to evaluate the association between comorbidity and lung cancer mortality using a competitive risk approach. During a median follow-up of 11 years, 1,320/9,579 (13.7%) individuals developed lung cancer, of which 886 (67.1%) succumbed to lung cancer and 875 of the 9,579 individuals (9.1%) succumbed due to other causes. The severity of comorbidity was associated with higher lung cancer-specific mortality; low to moderate comorbidity exhibited a hazard ratio (HR) of 2.86 [95% confidence interval (CI), 1.17-7.02] and severe comorbidity exhibited an HR of 5.16 (95% CI, 2.07-12.89). Furthermore, the CCI score determined that the severity of comorbidity increased the risk of lung cancer-specific mortality. Thus, CCI score is a good predictor of lung cancer-specific mortality and the use of comorbidity burdens in the clinical management of lung cancer is recommended.
KW - Comorbidities
KW - Lung cancer-specific mortality
KW - Other-cause mortality
UR - http://www.scopus.com/inward/record.url?scp=84923205813&partnerID=8YFLogxK
U2 - 10.3892/ol.2015.2916
DO - 10.3892/ol.2015.2916
M3 - Article
AN - SCOPUS:84923205813
SN - 1792-1074
VL - 9
SP - 1902
EP - 1906
JO - Oncology Letters
JF - Oncology Letters
IS - 4
ER -