TY - JOUR
T1 - Immunohistochemical expression of the PRO2268 protein in psoriasis vulgaris skin
AU - Douroudis, Konstantinos
AU - Sirotkina, Meeli
AU - Kingo, Külli
AU - Mössner, Rotraut
AU - Koks, Sulev
N1 - Funding Information:
We thank Kaupo Teesalu from the Institute of General and Molecular Pathology, University of Tartu, for his comments in the manuscript. This study was supported by a grant from the European Union through the European Regional Development Fund and the Archimedes Foundation ; by the Estonian Ministry of Education , Grant No. SF0180043s07 ; and by the Estonian Science Foundation , Grant No. 7549 .
PY - 2011/6
Y1 - 2011/6
N2 - The PRO2268 gene encodes for the PRO2268 molecule and maps to a chromosomal region (12q14), which clusters genes with a key role in immune signaling. Although the PRO2268 protein is as yet of unknown function, we should not exclude the possibility that the PRO2268 gene, because of its location, might have a distinct role in autoimmunity and inflammation. The aim of the present study was to investigate the expression pattern of the PRO2268 protein in psoriasis skin. Formalin-fixed paraffin-embedded sections from normal and psoriasis skin tissue were studied immunohistochemically using custom-ordered antibodies (anti-PRO2268#1 and anti-PRO2268#2) against the PRO2268. The present study revealed an expression of the anti-PRO2268#2 in the inflammatory infiltrate, and suggesting a possible role for the PRO2268 molecule in pathophysiology of psoriasis, which needs further investigation.
AB - The PRO2268 gene encodes for the PRO2268 molecule and maps to a chromosomal region (12q14), which clusters genes with a key role in immune signaling. Although the PRO2268 protein is as yet of unknown function, we should not exclude the possibility that the PRO2268 gene, because of its location, might have a distinct role in autoimmunity and inflammation. The aim of the present study was to investigate the expression pattern of the PRO2268 protein in psoriasis skin. Formalin-fixed paraffin-embedded sections from normal and psoriasis skin tissue were studied immunohistochemically using custom-ordered antibodies (anti-PRO2268#1 and anti-PRO2268#2) against the PRO2268. The present study revealed an expression of the anti-PRO2268#2 in the inflammatory infiltrate, and suggesting a possible role for the PRO2268 molecule in pathophysiology of psoriasis, which needs further investigation.
KW - Immunohistochemistry
KW - PRO2268
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=79955752808&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2011.03.002
DO - 10.1016/j.humimm.2011.03.002
M3 - Article
C2 - 21414369
AN - SCOPUS:79955752808
SN - 0198-8859
VL - 72
SP - 522
EP - 524
JO - Human Immunology
JF - Human Immunology
IS - 6
ER -