Immunohistochemical expression of the PRO2268 protein in psoriasis vulgaris skin

Konstantinos Douroudis*, Meeli Sirotkina, Külli Kingo, Rotraut Mössner, Sulev Koks

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The PRO2268 gene encodes for the PRO2268 molecule and maps to a chromosomal region (12q14), which clusters genes with a key role in immune signaling. Although the PRO2268 protein is as yet of unknown function, we should not exclude the possibility that the PRO2268 gene, because of its location, might have a distinct role in autoimmunity and inflammation. The aim of the present study was to investigate the expression pattern of the PRO2268 protein in psoriasis skin. Formalin-fixed paraffin-embedded sections from normal and psoriasis skin tissue were studied immunohistochemically using custom-ordered antibodies (anti-PRO2268#1 and anti-PRO2268#2) against the PRO2268. The present study revealed an expression of the anti-PRO2268#2 in the inflammatory infiltrate, and suggesting a possible role for the PRO2268 molecule in pathophysiology of psoriasis, which needs further investigation.

Original languageEnglish
Pages (from-to)522-524
Number of pages3
JournalHuman Immunology
Issue number6
Publication statusPublished - Jun 2011
Externally publishedYes


  • Immunohistochemistry
  • PRO2268
  • Psoriasis


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