Identification and characterization of the first cathelicidin from sea snakes with potent antimicrobial and antiinflammatory activity and special mechanism

Lin Wei, Jiuxiang Gao, Shumin Zhang, Sijin Wu, Zeping Xie, Guiying Ling, Yi Qun Kuang, Yongliang Yang, Haining Yu*, Yipeng Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

Background: Cathelicidins are a family of vertebrate antimicrobial peptides that play pivotal roles in host immune defense against microbial invasions. Results: A novel cathelicidin (Hc-CATH) with potent antimicrobial and anti-inflammatory activity and a special mechanism was identified from the sea snake Hydrophis cyanocinctus. Conclusion: Hc-CATH is a potent candidate for the development of peptide antibiotics. Significance: Hc-CATH is the first cathelicidin identified from sea snakes and possesses a special anti-inflammatory mechanism.

Original languageEnglish
Pages (from-to)16633-16652
Number of pages20
JournalJournal of Biological Chemistry
Volume290
Issue number27
DOIs
Publication statusPublished - 3 Jul 2015
Externally publishedYes

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