Hybridizing experimental paradigms to increase high throughput of neurobehavioral data

Although traditional (relatively simple and mostly single-domain) animal models of brain disorders continue to dominate biological psychiatry, combining experimental paradigms in an intelligent manner can save time, minimize the use of resources, and increase throughput of neurobehavioral data. This approach, also termed "hybridization of models," not only enables innovative modeling of neuropsychiatric disorders (through broad and thorough investigation of complex phenotypical characteristics) but contributes to the improvement of research ethics by following two of the 3R principles - Reduction [of animal numbers] and Refinement [of the research process by employing less distressful procedures]. This chapter will discuss methodological aspects and multiple benefits of using "hybrid" experimental paradigms in neurobehavioral research.