Hybridizing behavioral models: A possible solution to some problems in neurophenotyping research?

Allan V. Kalueff*, Justin L. LaPorte, Dennis L. Murphy, Kenneth Sufka

*Corresponding author for this work

Research output: Other contributionpeer-review

25 Citations (Scopus)


The use of batteries of single-domain tests for neurophenotyping research is a common strategy to achieve higher data density and explore different behavioral domains. This approach, however, is accompanied by several methodological challenges, briefly discussed here. As an alternative, this paper advocates the wider use of extensive "hybrid" protocols that assess multiple domains in parallel, or logically/logistically combine experimental paradigms, in a way that disproportionately maximizes the number of tested phenotypes per experimental manipulation. Several examples of this approach are given in this paper, demonstrating the potential to reduce time, cost and subject requirements for the experiments. Offering behavioral analyses that are lacking in the standard single-domain tests, such "hybrid" models enable innovative modeling of neuropsychiatric disorders by more thorough and broader investigation of complex phenotypical characteristics.

Original languageEnglish
Number of pages7
Publication statusPublished - 1 Jul 2008
Externally publishedYes

Publication series

NameProgress in Neuro-Psychopharmacology and Biological Psychiatry
ISSN (Print)0278-5846


  • Behavioral phenotyping
  • Experimental models
  • High-throughput testing
  • Research strategies
  • Single and multiple domains


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