HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population

K. Douroudis*, K. Tarassi, T. Athanassiades, F. Giannakopoulos, A. Kominakis, N. Thalassinos, Ch Papasteriades

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

It is well established that genetic factors play an important role in the pathogenesis of osteoporosis, a common condition characterized by reduced bone mass and increased fracture risk. The major histocompatibility complex in humans, known as human leukocyte antigen (HLA) region, is the most polymorphic human genetic system and it is known as a cluster of genetic markers, associated with several diseases. In order to evaluate the contribution of HLA alleles in bone mass loss, polymorphisms in the HLA class I (-A, -B and -Cw) and class II (-DR and -DQ) antigens were studied in 126 postmenopausal women of Greek origin. It was found that HLA-B7 (P = 0.069), -DR15 (P = 0.019) and -DQ6 (P = 0.026) were associated with a lower bone mineral density measured at the forearm. This study shows a significant association between HLA alleles and bone mass loss in the population studied.

Original languageEnglish
Pages (from-to)592-596
Number of pages5
JournalTissue Antigens
Volume69
Issue number6
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Keywords

  • BMD
  • HLA
  • Osteoporosis
  • Polymorphisms

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