Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review

Enakshi Sivasudhan, Neil Blake, Zhiliang Lu, Jia Meng, Rong Rong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)

Abstract

With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC.

Original languageEnglish
Article number741
JournalCells
Volume11
Issue number4
DOIs
Publication statusPublished - 21 Feb 2022

Keywords

  • Cancer hallmarks
  • HBx protein
  • Hepatitis B virus
  • Hepatocellular carcinoma
  • Therapeutics

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