Glycosyl-nucleolipids as new bioinspired amphiphiles

Laurent Latxague, Amit Patwa, Eric Amigues, Philippe Barthélémy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Four new Glycosyl-NucleoLipid (GNL) analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies (surface tension measurements, differential scanning calorimetry) indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity (lowerγlim) compared to the first generation of GNFs.

Original languageEnglish
Pages (from-to)12241-12263
Number of pages23
Issue number10
Publication statusPublished - Oct 2013
Externally publishedYes


  • Amphiphiles
  • Fluorocarbon
  • Glycosyl
  • Nucleolipid
  • Nucleoside
  • Surface tension


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