Genetic animal models of anxiety

Rupert J. Egan, Carisa L. Bergner, Peter C. Hart, Justin L. Laporte, Allan V. Kalueff

Research output: Chapter in Book or Report/Conference proceedingChapterpeer-review


Conditions such as generalized anxiety disorder, panic disorder, social phobia, specific phobia, obsessive-compulsive disorder, and post-traumatic stress disorder cause undue suffering and economic burden on a substantial portion of our society. The prevalence and serious debilitating effects of anxiety disorders increases the necessity for fast and efficacious understanding of the neurobiological pathways associated with these maladies. While the neural underpinnings of this spectrum may have been identified, further analysis is necessary to generate pharmacologically significant data. The development of new molecular genetics techniques applied towards the generation of specific knockout models with anxiety-like phenotypes have been instrumental to our understanding of anxiety spectrum disorders due to their specificity of effected targets. This chapter will discuss the individual anxiety spectrum disorders with a focus on the animal models displaying relevant phenotypes for neurobehavioral research.

Original languageEnglish
Title of host publicationTransgenic and Mutant Tools to Model Brain Disorders
EditorsAllan V. Kalueff, Carisa L. Bergner
Number of pages11
Publication statusPublished - 2010
Externally publishedYes

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Anmal models
  • Anxiety
  • Anxiety spectrum disorders
  • Exploration
  • Fear


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