TY - JOUR
T1 - Galectin-3
T2 - A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis
AU - Sayed, Ahmed
AU - Munir, Malak
AU - Attia, Mohamed S.
AU - Alghamdi, Badrah S.
AU - Ashraf, Ghulam Md
AU - Bahbah, Eshak I.
AU - Elfil, Mohamed
N1 - Publisher Copyright:
© 2022 Ahmed Sayed et al.
PY - 2022
Y1 - 2022
N2 - Stroke, whether ischemic or haemorrhagic, is one of the main causes of mortality and disability all over the world, which entails huge burdens in both healthcare environments as well as social and economic aspects of life. Therefore, there is a continuous search for novel reliable biomarkers that can enhance the recognition of stroke events in a timely manner and predict the clinical outcomes following a stroke event. Galectins are a group of proteins expressed by many types of cells and tissues including vasculature, certain immune cells, fibroblasts, and gastrointestinal epithelial cells. These proteins vary in their structure and configuration according to their type and have a diversity of functions according to the type of tissue they are expressed in. Among these proteins, a few studies investigated mainly the roles played by galectin-1 (Gal-1) and galectin-3 (Gal-3) in the molecular mechanisms of atherosclerosis and in brain tissue remodeling after a stroke event. In this review, we present an updated overview of the current understanding of Gal-3's functions and implications in stroke occurrence and the response of the brain tissue to stroke events, which may be a key to its utility as a predictor of stroke incidence and clinical prognosis in the future.
AB - Stroke, whether ischemic or haemorrhagic, is one of the main causes of mortality and disability all over the world, which entails huge burdens in both healthcare environments as well as social and economic aspects of life. Therefore, there is a continuous search for novel reliable biomarkers that can enhance the recognition of stroke events in a timely manner and predict the clinical outcomes following a stroke event. Galectins are a group of proteins expressed by many types of cells and tissues including vasculature, certain immune cells, fibroblasts, and gastrointestinal epithelial cells. These proteins vary in their structure and configuration according to their type and have a diversity of functions according to the type of tissue they are expressed in. Among these proteins, a few studies investigated mainly the roles played by galectin-1 (Gal-1) and galectin-3 (Gal-3) in the molecular mechanisms of atherosclerosis and in brain tissue remodeling after a stroke event. In this review, we present an updated overview of the current understanding of Gal-3's functions and implications in stroke occurrence and the response of the brain tissue to stroke events, which may be a key to its utility as a predictor of stroke incidence and clinical prognosis in the future.
UR - http://www.scopus.com/inward/record.url?scp=85126415994&partnerID=8YFLogxK
U2 - 10.1155/2022/2924773
DO - 10.1155/2022/2924773
M3 - Article
C2 - 35281427
AN - SCOPUS:85126415994
SN - 0962-9351
VL - 2022
JO - Mediators of Inflammation
JF - Mediators of Inflammation
M1 - 2924773
ER -