Free radical scavenging, thrombolytic and cytotoxic effects of the medicinal herb, crassocephalum crepidioides

Md Tanvir Kabir*, Mayesha Samiha, Hasina Yasmin, Mohammed S. Rahman, Md Sohanur Rahman, Ghulam Md Ashraf, Raushanara Akter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Crassocephalum crepidioides belongs to the Asteraceae family and the leaves of the plant were used in the phytochemical screening. The objective of this study was phytochemical analysis of C. crepidioides in order to evaluate its antioxidant, thrombolytic and cytotoxic effects. In this study, DPPH assay and total phenolic content (TPC) were used to evaluate the antioxidant property. Brine shrimp lethality test was performed to find the cytotoxicity. The TPC of methanolic extract of C. crepidioides was 637.22 mg/gm and gallic acid was standard in this procedure. The IC50 value of the plant extract of DPPH assay was 136.016 μg/mL obtained by using ascorbic acid as reference standard. Furthermore, the obtained IC50 value of ascorbic acid was 94.12 μg/mL. In this study, lethal concentrations of vincristine sulfate and the plant extract were 3.064 μg/mL and 69.245 μg/mL respectively. Indeed, the plant exhibited significant antioxidant, cytotoxic and thrombolytic activity.

Original languageEnglish
Pages (from-to)2205-2210
Number of pages6
JournalResearch Journal of Pharmacy and Technology
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 2021
Externally publishedYes

Keywords

  • Antioxidant
  • Cytotoxicity
  • DPPH assay
  • Thrombolytic activity
  • Total phenolic content

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