TY - GEN
T1 - Fabrication of 3D scaffolds via E-jet printing for tendon tissue repair
AU - Wu, Y.
AU - Wong, Y. S.
AU - Fuh, J. Y.H.
AU - Sun, J.
N1 - Publisher Copyright:
Copyright © 2015 by ASME.
PY - 2015
Y1 - 2015
N2 - Current clinical grafts used in tendon treatment are subject to several restrictions and there is a significant demand for alternative engineered tissue. The previously reported tendon scaffolds mainly based on electrospinning and textile technologies showed promising results for tendon regeneration. However, limitations, such as small pore size, nutrition transmission, cell attachment, exist universally in such scaffolds. In this work, a novel tissue engineered polycaprolactone (PCL) tendon scaffold based on electrohydrodynamic jet printing (E-Jetting) was developed for investigation. In preliminary in-vitro study, human tenocytes were seeded in scaffolds with pore size of ~106 μm to investigate the cell attachment, morphology and alignment. This study suggested that E-jetted tendon scaffold highly mimicked hierarchical construction from fiber to fascicle level of the native tendon, and has potential to be an alternative tendon regeneration tool.
AB - Current clinical grafts used in tendon treatment are subject to several restrictions and there is a significant demand for alternative engineered tissue. The previously reported tendon scaffolds mainly based on electrospinning and textile technologies showed promising results for tendon regeneration. However, limitations, such as small pore size, nutrition transmission, cell attachment, exist universally in such scaffolds. In this work, a novel tissue engineered polycaprolactone (PCL) tendon scaffold based on electrohydrodynamic jet printing (E-Jetting) was developed for investigation. In preliminary in-vitro study, human tenocytes were seeded in scaffolds with pore size of ~106 μm to investigate the cell attachment, morphology and alignment. This study suggested that E-jetted tendon scaffold highly mimicked hierarchical construction from fiber to fascicle level of the native tendon, and has potential to be an alternative tendon regeneration tool.
UR - http://www.scopus.com/inward/record.url?scp=84945151894&partnerID=8YFLogxK
U2 - 10.1115/MSEC20159367
DO - 10.1115/MSEC20159367
M3 - Conference Proceeding
AN - SCOPUS:84945151894
T3 - ASME 2015 International Manufacturing Science and Engineering Conference, MSEC 2015
BT - Materials; Biomanufacturing; Properties, Applications and Systems; Sustainable Manufacturing
PB - American Society of Mechanical Engineers
T2 - ASME 2015 International Manufacturing Science and Engineering Conference, MSEC 2015
Y2 - 8 June 2015 through 12 June 2015
ER -