Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated with Dysmenorrhea

Anastasia Tsigkou*, Fernando M. Reis, Pasquapina Ciarmela, Meng H. Lee, Bingjie Jiang, Claudia Tosti, Fang Rong Shen, Zhendan Shi, You Guo Chen, Felice Petraglia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Uterine leiomyoma is the most common benign neoplasm of female reproductive system, found in about 50% of women in reproductive age. The mechanisms of leiomyoma growth include cell proliferation, which is modulated by growth factors, and deposition of extracellular matrix (ECM). Activin A and myostatin are growth factors that play a role in proliferation of leiomyoma cells. Matrix metalloproteinases (MMPs) are known for their ability to remodel the ECM in different biological systems. The aim of this study was to evaluate the expression levels of activin βA-subunit, myostatin, and MMP14 messenger RNAs (mRNAs) in uterine leiomyomas and the possible correlation of these factors with clinical features of the disease. Matrix metalloproteinase 14 was highly expressed in uterine leiomyoma and correlated with myostatin and activin A mRNA expression. Moreover, MMP14 and myostatin mRNA expression correlated significantly and directly with the intensity of dysmenorrhea. Overall, the present findings showed that MMP14 mRNA is highly expressed in uterine leiomyoma, where it correlates with the molecular expression of growth factors and is further increased in cases of intense dysmenorrhea.

Original languageEnglish
Pages (from-to)1597-1602
Number of pages6
JournalReproductive Sciences
Issue number12
Publication statusPublished - 1 Dec 2015


  • MMP14
  • abnormal uterine bleeding
  • activin-A
  • dysmenorrhea
  • leiomyoma
  • matrix metalloproteinase
  • myostatin

Cite this