Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

Victor J. Hruby*, Minying Cai, Paolo Grieco, Guoxia Han, Malcolm Kavarana, Dev Trivedi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


The melanotropin peptides α-MSHH, γ-MSH, and β-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.

Original languageEnglish
Pages (from-to)12-20
Number of pages9
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2003
Externally publishedYes


  • Agonists
  • Antagonists
  • Conformational constraint
  • Melanocortin receptors
  • Melanotropin peptides
  • Receptor selective melanotropins
  • α-melanocyte stimulating hormone (α-MSH)
  • γ-melanocyte-stimulating hormone (γ-MSH)

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