Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

Victor J. Hruby; Minying Cai; Paolo Grieco; Guoxia Han; Malcolm Kavarana; Dev Trivedi

doi:10.1111/j.1749-6632.2003.tb03157.x

Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

Victor J. Hruby^*, Minying Cai, Paolo Grieco, Guoxia Han, Malcolm Kavarana, Dev Trivedi

^*Corresponding author for this work

Department of Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The melanotropin peptides α-MSHH, γ-MSH, and β-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.

Original language	English
Pages (from-to)	12-20
Number of pages	9
Journal	Annals of the New York Academy of Sciences
Volume	994
DOIs	https://doi.org/10.1111/j.1749-6632.2003.tb03157.x
Publication status	Published - 2003
Externally published	Yes

Keywords

Agonists
Antagonists
Conformational constraint
Melanocortin receptors
Melanotropin peptides
Receptor selective melanotropins
α-melanocyte stimulating hormone (α-MSH)
γ-melanocyte-stimulating hormone (γ-MSH)

Access to Document

10.1111/j.1749-6632.2003.tb03157.x

Cite this

@article{42a5186e4adb45dfaf1bb80de8f07c09,

title = "Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors",

abstract = "The melanotropin peptides α-MSHH, γ-MSH, and β-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.",

keywords = "Agonists, Antagonists, Conformational constraint, Melanocortin receptors, Melanotropin peptides, Receptor selective melanotropins, α-melanocyte stimulating hormone (α-MSH), γ-melanocyte-stimulating hormone (γ-MSH)",

author = "Hruby, {Victor J.} and Minying Cai and Paolo Grieco and Guoxia Han and Malcolm Kavarana and Dev Trivedi",

year = "2003",

doi = "10.1111/j.1749-6632.2003.tb03157.x",

language = "English",

volume = "994",

pages = "12--20",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

}

TY - JOUR

T1 - Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

AU - Hruby, Victor J.

AU - Cai, Minying

AU - Grieco, Paolo

AU - Han, Guoxia

AU - Kavarana, Malcolm

AU - Trivedi, Dev

PY - 2003

Y1 - 2003

N2 - The melanotropin peptides α-MSHH, γ-MSH, and β-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.

AB - The melanotropin peptides α-MSHH, γ-MSH, and β-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.

KW - Agonists

KW - Antagonists

KW - Conformational constraint

KW - Melanocortin receptors

KW - Melanotropin peptides

KW - Receptor selective melanotropins

KW - α-melanocyte stimulating hormone (α-MSH)

KW - γ-melanocyte-stimulating hormone (γ-MSH)

UR - http://www.scopus.com/inward/record.url?scp=0038389443&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2003.tb03157.x

DO - 10.1111/j.1749-6632.2003.tb03157.x

M3 - Article

C2 - 12851293

AN - SCOPUS:0038389443

SN - 0077-8923

VL - 994

SP - 12

EP - 20

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors

Abstract

Keywords

Access to Document

Other files and links

Cite this