Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia

Md Sahab Uddin; Md Motiar Rahman; Mohammad Abu Sufian; Philippe Jeandet; Ghulam Md Ashraf; May N. Bin-Jumah; Shaker A. Mousa; Mohamed M. Abdel-Daim; Muhammad Furqan Akhtar; Ammara Saleem; Md Shah Amran

doi:10.3389/fphys.2020.567678

Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia

Md Sahab Uddin^*, Md Motiar Rahman, Mohammad Abu Sufian, Philippe Jeandet, Ghulam Md Ashraf, May N. Bin-Jumah, Shaker A. Mousa, Mohamed M. Abdel-Daim, Muhammad Furqan Akhtar, Ammara Saleem, Md Shah Amran

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Alzheimer’s disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer’s dementia.

Original language	English
Article number	567678
Journal	Frontiers in Physiology
Volume	11
DOIs	https://doi.org/10.3389/fphys.2020.567678
Publication status	Published - 27 Jan 2021
Externally published	Yes

Keywords

adipocyte dysfunction
adipokine
AdipoQ
Alzheimer’s disease
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fphys.2020.567678

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title = "Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer{\textquoteright}s Dementia",

abstract = "Alzheimer{\textquoteright}s disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer{\textquoteright}s dementia.",

keywords = "adipocyte dysfunction, adipokine, AdipoQ, Alzheimer{\textquoteright}s disease, obesity",

author = "Uddin, {Md Sahab} and Rahman, {Md Motiar} and Sufian, {Mohammad Abu} and Philippe Jeandet and Ashraf, {Ghulam Md} and Bin-Jumah, {May N.} and Mousa, {Shaker A.} and Abdel-Daim, {Mohamed M.} and Akhtar, {Muhammad Furqan} and Ammara Saleem and Amran, {Md Shah}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Uddin, Rahman, Sufian, Jeandet, Ashraf, Bin-Jumah, Mousa, Abdel-Daim, Akhtar, Saleem and Amran.",

year = "2021",

month = jan,

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doi = "10.3389/fphys.2020.567678",

language = "English",

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AU - Uddin, Md Sahab

AU - Rahman, Md Motiar

AU - Sufian, Mohammad Abu

AU - Jeandet, Philippe

AU - Ashraf, Ghulam Md

AU - Bin-Jumah, May N.

AU - Mousa, Shaker A.

AU - Abdel-Daim, Mohamed M.

AU - Akhtar, Muhammad Furqan

AU - Saleem, Ammara

AU - Amran, Md Shah

PY - 2021/1/27

Y1 - 2021/1/27

N2 - Alzheimer’s disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer’s dementia.

AB - Alzheimer’s disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer’s dementia.

KW - adipocyte dysfunction

KW - adipokine

KW - AdipoQ

KW - Alzheimer’s disease

KW - obesity

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DO - 10.3389/fphys.2020.567678

M3 - Review article

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SN - 1664-042X

VL - 11

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 567678

ER -

Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer’s Dementia

Abstract

Keywords

UN SDGs

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