Experimental approaches to modeling delirium in zebrafish (Danio rerio)

Gleb O. Maslov, Tatyana O. Kolesnikova, Konstantin N. Zabegalov, Allan V. Kalueff*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Delirium is an acute psychiatric syndrome characterized by impaired attention, perception and orientation in space. Albeit known for millennia, the mechanisms and risk factors of delirium remain poorly understood. Experimental animal models, especially rodents, become widely used to understand these pathogenetic aspects. However, a new model organism — zebrafish (Danio rerio) also has promise in this field. Discussed here, recent behavioral tests and protocols for zebrafish enable assessing their behavioral and cognitive function, and its experimental modulation by deliriant drugs and other factors.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalReviews on Clinical Pharmacology and Drug Therapy
Issue number2
Publication statusPublished - 2022
Externally publishedYes


  • delirium
  • experimental models
  • zebrafish


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