Evaluating and adjusting for premature censoring of progression-free survival

Mark Rothmann*, Kallappa Koti, Kyung Yul Lee, Hong Laura Lu, Yuan Li Shen, Jenny J. Zhang, Mei Jin, Haojin Zhou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The intent-to-treat principle, grouping subjects as they were randomized and following all subjects to the endpoint or the end of study, allows valid statistical comparisons. Progression-free survival (PFS) has been used as a decision-making endpoint in oncology. It can be difficult to have a meaningful intent-to-treat analysis of PFS as some studies have extensive loss to follow-up for PFS. In the analysis, subjects lost to follow-up for PFS have their PFS times censored, with the censoring treated as noninformative. We use remaining overall survival to investigate whether premature censoring for PFS is informative and the potential bias in treating such censoring as noninformative.

Original languageEnglish
Pages (from-to)1091-1105
Number of pages15
JournalJournal of Biopharmaceutical Statistics
Issue number5
Publication statusPublished - 3 Sept 2013
Externally publishedYes


  • Loss to follow-up
  • Overall survival
  • Progression-free survival


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