Erratum: Understanding taurine CNS activity using alternative zebrafish models (Neuroscience & Biobehavioral Reviews (2017) 83 (525–539) (S0149763417303512) (10.1016/j.neubiorev.2017.09.008))

Nathana J. Mezzomo*, Barbara D. Fontana, Allan V. Kalueff, Leonardo J.G. Barcellos, Denis B. Rosemberg

*Corresponding author for this work

Research output: Contribution to journalComment/debate

17 Citations (Scopus)

Abstract

Taurine is a highly abundant “amino acid” in the brain. Although the potential neuroactive role of taurine in vertebrates has long been recognized, the underlying molecular mechanisms related to its pleiotropic effects in the brain remain poorly understood. Due to the genetic tractability, rich behavioral repertoire, neurochemical conservation, and small size, the zebrafish (Danio rerio) has emerged as a powerful candidate for neuropsychopharmacology investigation and in vivo drug screening. Here, we summarize the main physiological roles of taurine in mammals, including neuromodulation, osmoregulation, membrane stabilization, and antioxidant action. In this context, we also highlight how zebrafish models of brain disorders may present interesting approaches to assess molecular mechanisms underlying positive effects of taurine in the brain. Finally, we outline recent advances in zebrafish drug screening that significantly improve neuropsychiatric translational research and small molecule screens.

Original languageEnglish
Pages (from-to)471-485
Number of pages15
JournalNeuroscience and Biobehavioral Reviews
Volume90
DOIs
Publication statusPublished - Jul 2018
Externally publishedYes

Keywords

  • Brain disorder
  • Neural function
  • Neuropsychopharmacology
  • Taurine
  • Zebrafish

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