TY - JOUR
T1 - Epigenetic Modifications by Estrogen and Androgen in Alzheimer’s Disease
AU - Kumar, Rajnish
AU - Fatima, Faiza
AU - Yadav, Garima
AU - Singh, Simran
AU - Haldar, Subhagata
AU - Alexiou, Athanasios
AU - Md Ashraf, Ghulam
N1 - Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - For the development and maintenance of neuron networks in the brain, epigenetic mechanisms are necessary, as indicated by recent findings. This includes some of the high-order brain pro-cesses, such as behavior and cognitive functions. Epigenetic mechanisms could influence the pathophysiology or etiology of some neuronal diseases, altering disease susceptibility and therapy respons-es. Recent studies support epigenetic dysfunctions in neurodegenerative and psychiatric conditions, such as Alzheimer's disease (AD). These dysfunctions in epigenetic mechanisms also play crucial roles in the transgenerational effects of the environment on the brain and subsequently in the inher-itance of pathologies. The possible role of gonadal steroids in the etiology and progression of neuro-degenerative diseases, including Alzheimer’s disease, has become the subject of a growing body of research over the last 20 years. Recent scientific findings suggest that epigenetic changes, driven by estrogen and androgens, play a vital role in brain functioning. Therefore, exploring the role of estrogen and androgen-based epigenetic changes in the brain is critical for the deeper understanding of AD. This review highlights the epigenetic modifications caused by these two gonadal steroids and the possible therapeutic strategies for AD.
AB - For the development and maintenance of neuron networks in the brain, epigenetic mechanisms are necessary, as indicated by recent findings. This includes some of the high-order brain pro-cesses, such as behavior and cognitive functions. Epigenetic mechanisms could influence the pathophysiology or etiology of some neuronal diseases, altering disease susceptibility and therapy respons-es. Recent studies support epigenetic dysfunctions in neurodegenerative and psychiatric conditions, such as Alzheimer's disease (AD). These dysfunctions in epigenetic mechanisms also play crucial roles in the transgenerational effects of the environment on the brain and subsequently in the inher-itance of pathologies. The possible role of gonadal steroids in the etiology and progression of neuro-degenerative diseases, including Alzheimer’s disease, has become the subject of a growing body of research over the last 20 years. Recent scientific findings suggest that epigenetic changes, driven by estrogen and androgens, play a vital role in brain functioning. Therefore, exploring the role of estrogen and androgen-based epigenetic changes in the brain is critical for the deeper understanding of AD. This review highlights the epigenetic modifications caused by these two gonadal steroids and the possible therapeutic strategies for AD.
KW - Alzheimer's disease
KW - androgen
KW - brain
KW - epigenetic modifications
KW - estrogen
KW - neuronal diseases
UR - http://www.scopus.com/inward/record.url?scp=85143644893&partnerID=8YFLogxK
U2 - 10.2174/1871527321666220225110501
DO - 10.2174/1871527321666220225110501
M3 - Review article
C2 - 35232367
AN - SCOPUS:85143644893
SN - 1871-5273
VL - 22
SP - 6
EP - 17
JO - CNS and Neurological Disorders - Drug Targets
JF - CNS and Neurological Disorders - Drug Targets
IS - 1
ER -