Epigallocatechin 3-gallate: From green tea to cancer therapeutics

Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav*, Md Imtaiyaz Hassan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

129 Citations (Scopus)

Abstract

Epigallocatechin 3-gallate (EGCG) possesses various biological functions, including anti-cancer and anti-inflammatory properties. EGCG is an abundant polyphenolic component originating from green tea extract that has exhibited versatile bioactivities in combating several cancers. This review highlights the pharmacological features of EGCG and its therapeutic implications in cancer and other metabolic diseases. It modulates numerous signaling pathways, regulating cells' undesired survival and proliferation, thus imparting strong tumor chemopreventive and therapeutic effects. EGCG initiates cell death through the intrinsic pathway and causes inhibition of EGFR, STAT3, and ERK pathways in several cancers. EGCG alters and inhibits ERK1/2, NF-κB, and Akt-mediated signaling, altering the Bcl-2 family proteins ratio and activating caspases in tumor cells. This review focuses on anti-cancer, anti-oxidant, anti-inflammatory, anti-angiogenesis, and apoptotic effects of EGCG. We further highlighted the potential of EGCG in different types of cancer, emphasizing clinical trials formulations that further improve our understanding of the therapeutic management of cancer and inflammatory diseases.

Original languageEnglish
Article number132135
JournalFood Chemistry
Volume379
DOIs
Publication statusPublished - 15 Jun 2022
Externally publishedYes

Keywords

  • Cancer therapy
  • Chemotherapy
  • Drug discovery
  • Epigallocatechin gallate
  • Green tea extracts
  • Natural products
  • Signaling pathways

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