Effects of nanoparticle size and radiation energy on copper-cysteamine nanoparticles for x-ray induced photodynamic therapy

Bindeshwar Sah, Jing Wu, Adam Vanasse, Nil Kanatha Pandey, Lalit Chudal, Zhenzhen Huang, Wenzhi Song, Hongmei Yu, Lun Ma, Wei Chen*, Michael P. Antosh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The Copper-cysteamine (Cu-Cy) nanoparticle is a novel sensitizer with a potential to increase the effectiveness of radiation therapy for cancer treatment. In this work, the effect of nanoparticle size and the energy of X-rays on the effectiveness of radiation therapy are investigated. The effect of the particle size on their performance is very complicated. The nanoparticles with an average size of 300 nm have the most intense photoluminescence, the nanoparticles with the average size of 100 nm have the most reactive oxygen species production upon X-ray irradiation, while the nanoparticles with the average size of 40 nm have the best outcome in the tumor suppression in mice upon X-ray irradiation. For energy, 90 kVp radiation resulted in smaller tumor sizes than 250 kVp or 350 kVp radiation energies. Overall, knowledge of the effect of nanoparticle size and radiation energy on radiation therapy outcomes could be useful for future applications of Cu-Cy nanoparticles.

Original languageEnglish
Article number1087
JournalNanomaterials
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2020
Externally publishedYes

Keywords

  • Copper-cysteamine nanoparticle
  • Mice
  • Photodynamic therapy
  • Radiation energies
  • Reactive oxygen species
  • Size
  • Tumor
  • X-ray

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