Effect of topiramate on interleukin 6 expression in the hippocampus of amygdala-kindled epileptic rats

Fei Ye, Xu Qin Chen, Guan Shui Bao*, Yin Hua, Zhe Dong Wang, Yi Chuan Bao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The objective of this study was to analyze the changes in expression and the possible functions of interleukin-6 (IL-6) in electrical kindling of the basolateral amygdala (BLA) in epileptic rats. Bipolar electrodes were implanted into the BLA of Sprague-Dawley rats, and the rats were then subjected to chronic electrical stimulation through the electrodes to induce kindling. The seizure characteristics and behavioral changes of the rats were observed, and electroencephalograms were recorded during and following kindling. The IL-6 mRNA expression in the hippocampi of the rats was analyzed using semi-quantitative reverse transcription-polymerase chain reaction, and control and topiramate (TPM)-treated groups were compared. The mean time-period required for kindling was 13.50±3.99 days, and the afterdischarge duration (ADD) measured between 21,450 and 119,720 msec. The expression of IL-6 mRNA was significantly upregulated in the kindled rats. TPM was able to depress the seizures and decrease the IL-6 level in the kindled rats. In conclusion, IL-6 mRNA was upregulated in the hippocampi of epileptic rats, and IL-6 may have participated in the process of kindling.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalExperimental and Therapeutic Medicine
Issue number1
Publication statusPublished - 2013
Externally publishedYes


  • Basolateral amygdale
  • Epilepsy
  • Interleukin-6
  • Kindling
  • Rat
  • Topiramate


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