EDTA and DTPA modified ligands as sequestering agents for uranyl decorporation

Antoine Leydier, Yi Lin, Guilhem Arrachart, Raphaël Turgis, Delphine Lecerclé, Alain Favre-Reguillon, Frédéric Taran, Marc Lemaire, Stéphane Pellet-Rostaing*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Synthesis of modified EDTA and DTPA ligands and determination of their binding affinities for the uranyl cation are described. Thanks to a screening method, based on a chromophoric complex displacement procedure, chelating properties were studied in aqueous media under various pH conditions for evaluation of their in vivo uranyl-removal efficacy. Each ligand showed a more or less pronounced affinity for uranium. Specific ligands based on EDTA or DTPA analogues containing sulfocatecholamide (CAMS) were found to exhibit a significant affinity towards uranyl ion in acidic, neutral or basic conditions.

Original languageEnglish
Pages (from-to)1163-1170
Number of pages8
JournalTetrahedron
Volume68
Issue number4
DOIs
Publication statusPublished - 28 Jan 2012
Externally publishedYes

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