@inproceedings{66b54422cd1d4884808d0c0ebc6ef52f,
title = "Dysregulated microRNA profile in HeLa cell lines induced by lupeol",
abstract = "Lupeol attracted lots of research attention because of its anticancer activity. This work presents the complete microRNA profile between lupeol treated HeLa cell lines and control group, and investigates the complete small RNA sequencing data analysis process, including microRNA annotation, novel microRNA prediction, dysregulated microRNA identification and microRNA target prediction. Based on single replicate data, we applied generalized fold change (GFOLD) algorithm to detect significant regulated microRNAs. Furthermore, we adopted GOmir to predict targets of some microRNAs which have received fully attention and perform ontology analysis. The experimental results indicate that the predicted microRNAs are highly correlated with carcinogenesis.",
keywords = "HeLa, lupeol, microRNA, small RNA sequencing",
author = "Xiyuan Lu and Cuihong Dai and Aiju Hou and Jie Cui and Dayou Cheng and Dechang Xu",
year = "2014",
doi = "10.1007/978-3-319-08171-7_7",
language = "English",
isbn = "9783319081700",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "71--80",
booktitle = "Bioinformatics Research and Applications - 10th International Symposium, ISBRA 2014, Proceedings",
note = "10th International Symposium on Bioinformatics Research and Applications, ISBRA 2014 ; Conference date: 28-06-2014 Through 30-06-2014",
}