Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma

Enakshi Sivasudhan, Neil Blake, Zhi Liang Lu, Jia Meng, Rong Rong*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Epidemiological data consistently rank hepatocellular carcinoma (HCC) as one of the leading causes of cancer-related deaths worldwide, often posing severe economic burden on health care. While the molecular etiopathogenesis associated with genetic and epigenetic modifications has been extensively explored, the biological influence of the emerging field of epitranscriptomics and its associated aberrant RNA modifications on tumorigenesis is a largely unexplored territory with immense potential for discovering new therapeutic approaches. In particular, the underlying cellular mechanisms of different hallmarks of hepatocarcinogenesis that are governed by the complex dynamics of m6A RNA methylation demand further investigation. In this review, we reveal the up-to-date knowledge on the mechanistic and functional link between m6A RNA methylation and pathogenesis of HCC.

Original languageEnglish
Article number642443
JournalFrontiers in Cell and Developmental Biology
Volume9
DOIs
Publication statusPublished - 1 Apr 2021

Keywords

  • cancer hallmarks
  • epitranscriptomics
  • erasers
  • hepatocellular carcinoma
  • m6A RNA methylation
  • readers
  • writers

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