TY - JOUR
T1 - Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
AU - Tsui, Ka Chun
AU - Roy, Jaydeep
AU - Chau, Sze Chun
AU - Wong, Kah Hui
AU - Shi, Lei
AU - Poon, Chi Him
AU - Wang, Yingyi
AU - Strekalova, Tatyana
AU - Aquili, Luca
AU - Chang, Raymond Chuen Chung
AU - Fung, Man Lung
AU - Song, You Qiang
AU - Lim, Lee Wei
N1 - Publisher Copyright:
Copyright © 2022 Tsui, Roy, Chau, Wong, Shi, Poon, Wang, Strekalova, Aquili, Chang, Fung, Song and Lim.
PY - 2022/7/28
Y1 - 2022/7/28
N2 - Alzheimer’s disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of Aβ plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High Aβ plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of Aβ plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of Aβ plaques were located in the amygdala, and the cerebellum; but no Aβ plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of Aβ plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of Aβ deposition in the brain and its inter-regional correlation. This suggests an association between Aβ plaque deposition and specific brain regions in AD pathogenesis.
AB - Alzheimer’s disease (AD) is the most common form of dementia. Although previous studies have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain regions, a comprehensive characterization of the rostro-caudal distribution of Aβ plaques in the brain and their inter-regional correlation remain unexplored. Our results demonstrated remarkable working and spatial memory deficits in 9-month-old 5xFAD mice compared to wildtype mice. High Aβ plaque load was detected in the somatosensory cortex, piriform cortex, thalamus, and dorsal/ventral hippocampus; moderate levels of Aβ plaques were observed in the motor cortex, orbital cortex, visual cortex, and retrosplenial dysgranular cortex; and low levels of Aβ plaques were located in the amygdala, and the cerebellum; but no Aβ plaques were found in the hypothalamus, raphe nuclei, vestibular nucleus, and cuneate nucleus. Interestingly, the deposition of Aβ plaques was positively associated with brain inter-regions including the prefrontal cortex, somatosensory cortex, medial amygdala, thalamus, and the hippocampus. In conclusion, this study provides a comprehensive morphological profile of Aβ deposition in the brain and its inter-regional correlation. This suggests an association between Aβ plaque deposition and specific brain regions in AD pathogenesis.
KW - 5xFAD
KW - Alzheimer’s disease
KW - amyloid-beta (AB)
KW - dementia
KW - morphology
KW - neuroanatomy
UR - http://www.scopus.com/inward/record.url?scp=85135872769&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2022.964336
DO - 10.3389/fnagi.2022.964336
M3 - Article
AN - SCOPUS:85135872769
SN - 1663-4365
VL - 14
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 964336
ER -