TY - JOUR
T1 - Dissecting Sex-Related Cognition between Alzheimer's Disease and Diabetes
T2 - From Molecular Mechanisms to Potential Therapeutic Strategies
AU - Ashraf, Ghulam Md
AU - Ebada, Mahmoud Ahmed
AU - Suhail, Mohd
AU - Ali, Ashraf
AU - Uddin, Md Sahab
AU - Bilgrami, Anwar L.
AU - Perveen, Asma
AU - Husain, Amjad
AU - Tarique, Mohd
AU - Hafeez, Abdul
AU - Alexiou, Athanasios
AU - Ahmad, Ausaf
AU - Kumar, Rajnish
AU - Banu, Naheed
AU - Najda, Agnieszka
AU - Sayed, Amany A.
AU - Albadrani, Ghadeer M.
AU - Abdel-Daim, Mohamed M.
AU - Peluso, Ilaria
AU - Barreto, George E.
N1 - Publisher Copyright:
© 2021 Ghulam Md Ashraf et al.
PY - 2021
Y1 - 2021
N2 - The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains.
AB - The brain is a sexually dimorphic organ that implies different functions and structures depending on sex. Current pharmacological approaches against different neurological diseases act distinctly in male and female brains. In all neurodegenerative diseases, including Alzheimer's disease (AD), sex-related outcomes regarding pathogenesis, prevalence, and response to treatments indicate that sex differences are important for precise diagnosis and therapeutic strategy. Pathogenesis of AD includes vascular dementia, and in most cases, this is accompanied by metabolic complications with similar features as those assembled in diabetes. This review discusses how AD-associated dementia and diabetes affect cognition in relation to sex difference, as both diseases share similar pathological mechanisms. We highlight potential protective strategies to mitigate amyloid-beta (Aβ) pathogenesis, emphasizing how these drugs act in the male and female brains.
UR - http://www.scopus.com/inward/record.url?scp=85103214639&partnerID=8YFLogxK
U2 - 10.1155/2021/4572471
DO - 10.1155/2021/4572471
M3 - Review article
C2 - 33747345
AN - SCOPUS:85103214639
SN - 1942-0900
VL - 2021
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 4572471
ER -
