Discovering the Potential of Natural Antioxidants in Age-Related Macular Degeneration: A Review

Kah Hui Wong; Hui Yin Nam; Sze Yuen Lew; Murali Naidu; Pamela David; Tengku Ain Kamalden; Siti Nurma Hanim Hadie; Lee Wei Lim

doi:10.3390/ph15010101

Discovering the Potential of Natural Antioxidants in Age-Related Macular Degeneration: A Review

Kah Hui Wong^*, Hui Yin Nam, Sze Yuen Lew, Murali Naidu, Pamela David, Tengku Ain Kamalden, Siti Nurma Hanim Hadie, Lee Wei Lim^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is a multifactorial disease associated with anatom-ical changes in the inner retina. Despite tremendous advances in clinical care, there is currently no cure for AMD. This review aims to evaluate the published literature on the therapeutic roles of natural antioxidants in AMD. A literature search of PubMed, Web of Science and Google Scholar for peer-reviewed articles published between 1 January 2011 and 31 October 2021 was undertaken. A total of 82 preclinical and 18 clinical studies were eligible for inclusion in this review. We identified active compounds, carotenoids, extracts and polysaccharides, flavonoids, formulations, vitamins and whole foods with potential therapeutic roles in AMD. We evaluated the integral cellular signaling pathways including the activation of antioxidant pathways and angiogenesis pathways orchestrating their mode of action. In conclusion, we examined the therapeutic roles of natural antioxidants in AMD which warrant further study for application in clinical practice. Our current understanding is that natural antioxidants have the potential to improve or halt the progression of AMD, and tailoring therapeutics to the specific disease stages may be the key to preventing irreversible vision loss.

Original language	English
Article number	101
Journal	Pharmaceuticals
Volume	15
Issue number	1
DOIs	https://doi.org/10.3390/ph15010101
Publication status	Published - Jan 2022
Externally published	Yes

Keywords

Age-related macular degeneration
Angiogenesis
Antioxidants
Oxidative damage
Retina

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10.3390/ph15010101

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title = "Discovering the Potential of Natural Antioxidants in Age-Related Macular Degeneration: A Review",

abstract = "Age-related macular degeneration (AMD) is a multifactorial disease associated with anatom-ical changes in the inner retina. Despite tremendous advances in clinical care, there is currently no cure for AMD. This review aims to evaluate the published literature on the therapeutic roles of natural antioxidants in AMD. A literature search of PubMed, Web of Science and Google Scholar for peer-reviewed articles published between 1 January 2011 and 31 October 2021 was undertaken. A total of 82 preclinical and 18 clinical studies were eligible for inclusion in this review. We identified active compounds, carotenoids, extracts and polysaccharides, flavonoids, formulations, vitamins and whole foods with potential therapeutic roles in AMD. We evaluated the integral cellular signaling pathways including the activation of antioxidant pathways and angiogenesis pathways orchestrating their mode of action. In conclusion, we examined the therapeutic roles of natural antioxidants in AMD which warrant further study for application in clinical practice. Our current understanding is that natural antioxidants have the potential to improve or halt the progression of AMD, and tailoring therapeutics to the specific disease stages may be the key to preventing irreversible vision loss.",

keywords = "Age-related macular degeneration, Angiogenesis, Antioxidants, Oxidative damage, Retina",

author = "Wong, {Kah Hui} and Nam, {Hui Yin} and Lew, {Sze Yuen} and Murali Naidu and Pamela David and Kamalden, {Tengku Ain} and Hadie, {Siti Nurma Hanim} and Lim, {Lee Wei}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

doi = "10.3390/ph15010101",

language = "English",

volume = "15",

journal = "Pharmaceuticals",

issn = "1424-8247",

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T1 - Discovering the Potential of Natural Antioxidants in Age-Related Macular Degeneration

T2 - A Review

AU - Wong, Kah Hui

AU - Nam, Hui Yin

AU - Lew, Sze Yuen

AU - Naidu, Murali

AU - David, Pamela

AU - Kamalden, Tengku Ain

AU - Hadie, Siti Nurma Hanim

AU - Lim, Lee Wei

PY - 2022/1

Y1 - 2022/1

N2 - Age-related macular degeneration (AMD) is a multifactorial disease associated with anatom-ical changes in the inner retina. Despite tremendous advances in clinical care, there is currently no cure for AMD. This review aims to evaluate the published literature on the therapeutic roles of natural antioxidants in AMD. A literature search of PubMed, Web of Science and Google Scholar for peer-reviewed articles published between 1 January 2011 and 31 October 2021 was undertaken. A total of 82 preclinical and 18 clinical studies were eligible for inclusion in this review. We identified active compounds, carotenoids, extracts and polysaccharides, flavonoids, formulations, vitamins and whole foods with potential therapeutic roles in AMD. We evaluated the integral cellular signaling pathways including the activation of antioxidant pathways and angiogenesis pathways orchestrating their mode of action. In conclusion, we examined the therapeutic roles of natural antioxidants in AMD which warrant further study for application in clinical practice. Our current understanding is that natural antioxidants have the potential to improve or halt the progression of AMD, and tailoring therapeutics to the specific disease stages may be the key to preventing irreversible vision loss.

AB - Age-related macular degeneration (AMD) is a multifactorial disease associated with anatom-ical changes in the inner retina. Despite tremendous advances in clinical care, there is currently no cure for AMD. This review aims to evaluate the published literature on the therapeutic roles of natural antioxidants in AMD. A literature search of PubMed, Web of Science and Google Scholar for peer-reviewed articles published between 1 January 2011 and 31 October 2021 was undertaken. A total of 82 preclinical and 18 clinical studies were eligible for inclusion in this review. We identified active compounds, carotenoids, extracts and polysaccharides, flavonoids, formulations, vitamins and whole foods with potential therapeutic roles in AMD. We evaluated the integral cellular signaling pathways including the activation of antioxidant pathways and angiogenesis pathways orchestrating their mode of action. In conclusion, we examined the therapeutic roles of natural antioxidants in AMD which warrant further study for application in clinical practice. Our current understanding is that natural antioxidants have the potential to improve or halt the progression of AMD, and tailoring therapeutics to the specific disease stages may be the key to preventing irreversible vision loss.

KW - Age-related macular degeneration

KW - Angiogenesis

KW - Antioxidants

KW - Oxidative damage

KW - Retina

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U2 - 10.3390/ph15010101

DO - 10.3390/ph15010101

M3 - Review article

AN - SCOPUS:85123062089

SN - 1424-8247

VL - 15

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 1

M1 - 101

ER -

Discovering the Potential of Natural Antioxidants in Age-Related Macular Degeneration: A Review

Abstract

Keywords

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