Directional assembly of a stapled α-helical peptide

Kuan Hu, Feng Yin, Ziyuan Zhou, Chenshan Lian, Yinghuan Liu, Chengjie Sun, Wenjun Li, Jianing Zhang, Zigang Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The De novo design of stapled peptide-based self-assemblies attracts vast interest, yet still remains challenging. The development of an oxidation trigger for peptide stapling and subsequent self-assembly is described here. A self-assembling sequence, Fmoc-R(RCEX)2-NH2, transformed from a random coil to an α-helical structure upon disulphide bonding of the flanking cysteine residues positioning at the i/i + 4 locations. The stapling form of this peptide enforces a conformational restraint that affords the driving force for self-assembly into nanorod/nanovesicle structures. Moreover, these assembled materials can transport siRNA into cancer cells and immediately release the cargo in a reductive environment.

Original languageEnglish
Pages (from-to)10484-10487
Number of pages4
JournalChemical Communications
Issue number70
Publication statusPublished - 2019
Externally publishedYes


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