TY - JOUR
T1 - Developing Peripheral Biochemical Biomarkers of Brain Disorders
T2 - Insights from Zebrafish Models
AU - Ilyin, Nikita P.
AU - Petersen, Elena V.
AU - Kolesnikova, Tatyana O.
AU - Demin, Konstantin A.
AU - Khatsko, Sergey L.
AU - Apuhtin, Kirill V.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© Pleiades Publishing, Ltd. 2024.
PY - 2024/2
Y1 - 2024/2
N2 - Abstract: High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience. These fish share some practical advantages over mammalian models together with high genetic homology and evolutionarily conserved biochemical and neurobehavioral phenotypes, thus enabling large-scale modeling of human brain diseases. Here, we review mounting evidence on peripheral biomarkers of brain disorders in zebrafish models, focusing on altered biochemistry (lipids, carbohydrates, proteins, and other non-signal molecules, as well as metabolic reactions and activity of enzymes). Collectively, these data strongly support the utility of zebrafish (from a systems biology standpoint) to study peripheral manifestations of brain disorders, as well as highlight potential applications of biochemical biomarkers in zebrafish models to biomarker-based drug discovery and development.
AB - Abstract: High prevalence of human brain disorders necessitates development of the reliable peripheral biomarkers as diagnostic and disease-monitoring tools. In addition to clinical studies, animal models markedly advance studying of non-brain abnormalities associated with brain pathogenesis. The zebrafish (Danio rerio) is becoming increasingly popular as an animal model organism in translational neuroscience. These fish share some practical advantages over mammalian models together with high genetic homology and evolutionarily conserved biochemical and neurobehavioral phenotypes, thus enabling large-scale modeling of human brain diseases. Here, we review mounting evidence on peripheral biomarkers of brain disorders in zebrafish models, focusing on altered biochemistry (lipids, carbohydrates, proteins, and other non-signal molecules, as well as metabolic reactions and activity of enzymes). Collectively, these data strongly support the utility of zebrafish (from a systems biology standpoint) to study peripheral manifestations of brain disorders, as well as highlight potential applications of biochemical biomarkers in zebrafish models to biomarker-based drug discovery and development.
KW - biomarker
KW - brain disorders
KW - epilepsy
KW - neurodegeneration
KW - peripheral
KW - stress
KW - zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85188257183&partnerID=8YFLogxK
U2 - 10.1134/S0006297924020160
DO - 10.1134/S0006297924020160
M3 - Review article
C2 - 38622104
AN - SCOPUS:85188257183
SN - 0006-2979
VL - 89
SP - 377
EP - 391
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
IS - 2
ER -
